Yasal tedbirler kapsamında; ülkeler tarafından düzenleyici otoritelerin kurularak uluslararası alanda işbirliklerinin ve veri akışının sağlanması, tedarik zincirinin sıkı denetime tabi tutularak izlenmesi, gerçek ilaç paketlemeleri üzerinde kopyalanamaz emblem-barkod oluşturulması, orijinal satıcılar için ortak emblem uygulaması, tedarik zincirinin elektronik olarak takibi, on line eczanelerin orijinalliğinin tespiti ve kamu ile paylaşılması, on-line eczane siteleri tarafından ilaç satışının yasaklanması veya on the net eczanelerin alan advertisementı almak için sıkı kurallara tabi tutulması gibi örnekler sayılabilir.
Devletler ise bu süreçte gelir ve vergi kaybı dışında, sınırlı sağlık araştırmaları bütçelerinin de bir kısmını yasadışı ilaç ticaretinin tespitine harcayarak kaynak da kaybetmektedir.
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